Illustration of intravenous infusion bag icon

MARGENZA is an infusion that was approved by the FDA in 2020

What does MARGENZA treat?

MARGENZA is a prescription medicine approved for use in combination with chemotherapy for the treatment of adult patients with metastatic HER2-positive breast cancer who have received two or more prior anti-HER2 regimens, at least one of which was for metastatic disease.

What does it mean to have HER2-positive metastatic breast cancer?

Some breast cancer cells have too much of a protein called human epidermal growth factor receptor 2, or HER2. This protein tells the cancer cells to grow. About 1 in 5 people with breast cancer have HER2-positive breast cancer.

How MARGENZA works

Scientific Illustration of MARGENZA attaching to a HER2 receptor on a tumor cell.

MARGENZA targets the HER2-positive receptors and may block the response to the chemical signals that tell the cancer cells to grow.

Scientific Illustration of MARGENZA recruiting natural killer cells to destroy cancer cells.

MARGENZA was engineered to improve how your body’s immune system works, enabling it to destroy the cancer cells.

Take a closer look at how MARGENZA works

A choice of chemotherapy

See What To Expect
Comforting image of doctor holding woman’s hands.

We're here to help

1-844-MED-MGNX (1-844-633-6469)
MARGENZA Access Support is available Monday–Friday 9 AM to 7 PM ET

Important Safety Information

What is the most important information I should know about MARGENZA?
MARGENZA can cause serious side effects, including:
  • Heart problems that may affect your heart’s ability to pump blood. Your doctor will run tests to monitor your heart function before and during treatment with MARGENZA. Based on test results, your doctor may hold or discontinue treatment with MARGENZA.
    • Tell your healthcare provider right away if you get any of the following signs and symptoms: new or worsening shortness of breath, coughing, feeling tired, swelling of the ankles or legs, swelling of the face, irregular heart beat or palpitations, sudden weight gain of more than 5 pounds in 24 hours, dizziness or feeling light-headed, or loss of consciousness.
  • Harm to your unborn baby. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with MARGENZA. Exposure to MARGENZA during pregnancy or within 4 months prior to conception can result in fetal harm.
    • If you are able to become pregnant, your healthcare provider should do a pregnancy test before you start treatment with MARGENZA.
    • Birth control should be used while receiving MARGENZA and for 4 months after your last dose of MARGENZA.
What are other possible serious side effects of MARGENZA?

Infusion-related reactions. MARGENZA is a medicine that is delivered into a vein through a needle as an infusion. MARGENZA has been associated with infusion-related reactions which can include fever, chills, joint pain, cough, dizziness, tiredness, nausea, vomiting, headache, sweating, fast heart rate, low blood pressure, itching, rash, hives, and shortness of breath. Your healthcare team will monitor you during treatment with MARGENZA and may slow or stop your infusion if you have side effects. You may need to permanently stop MARGENZA if you have a severe infusion reaction.

Before you receive MARGENZA, tell your doctor if you are breastfeeding. It is not known if MARGENZA could pass into breast milk and harm your baby.

What are the most common side effects of MARGENZA in combination with chemotherapy?

The most common side effects with MARGENZA in combination with chemotherapy are fatigue/weakness, nausea, diarrhea, vomiting, constipation, headache, fever, hair loss, abdominal pain, peripheral neuropathy (weakness, numbness, pain, and/or tingling in hands and feet), joint and muscle pain, cough, decreased appetite, shortness of breath, infusion-related reactions, redness/swelling and pain on the palms of the hands and soles of the feet (hand-foot syndrome), and pain in arms and legs.

You are encouraged to report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch or to MacroGenics at (844)-MED-MGNX (844-633-6469).

These are not all the possible side effects of MARGENZA. Your doctor may stop treatment if serious side effects happen. Be sure to contact your healthcare team right away if you have questions or are worried about any side effects.

What does MARGENZA treat?

MARGENZA is a prescription medicine approved for use in combination with chemotherapy for the treatment of adult patients with metastatic HER2-positive breast cancer who have received two or more prior anti-HER2 regimens, at least one of which was for metastatic disease.

Please see full Prescribing Information, including Boxed Warning.